Research papers W–Z

The information on this website is based on published scientific research. Most of the papers listed below are available on the Internet and DOI links have been added for all bar a few papers. PubMed links have been added for the remainder.

Last updated: March 2024

W

Walker IA, Nelson-Piercy C, Williamson C. Role of bile acid measurement in pregnancy. Annals of Clinical Biochemistry 2002; 39: 105–13. https://doi.org/10.1258%2F0004563021901856

Walker I, Chappell LC, Williamson C. Abnormal liver function tests in pregnancy. British Medical Journal 2013; 25: 347. https://doi.org/10.1136/bmj.f6055

Wander G, Neuberger F, Dhanjal MK, Nelson-Piercy C, Soh MC. Cytomegalovirus may mimic the presentation of intrahepatic cholestasis and hemolysis, elevated liver enzymes and low platelets in immunosuppressed pregnant women. Obstetric Medicine 2016; 9(3): 135–7. https://doi.org/10.1177/1753495X16641807.

Wang Y, Tang Y, Yang X, Xu J, Chen Y, Xu J, Hu S, Yi P. Immune dysfunction mediated by the cerna regulatory network in human placenta tissue of intrahepatic cholestasis pregnancy. Frontiers in Immunology 2022; 13: 883971. https://doi.org/10.3389/fimmu.2022.883971.

Wang Z, Liu S. [Changes of selenium concentration and glutathione peroxidase activity in maternal and cord blood in intrahepatic cholestasis of pregnancy]. Zhonghua Fu Chan Ke Za Zhi 2000; 35(9): 520–2. https://pubmed.ncbi.nlm.nih.gov/11775939/.

Wang Z, Liu S, Wang J. [Changes of selenium concentration in blood and placenta in intrahepatic cholestasis of pregnancy]. Zhonghua Fu Chan Ke Za Zhi 2000; 35(8): 476–8. https://pubmed.ncbi.nlm.nih.gov/11776202/.

Wang Z, Dong M, Chu H, He J. Increased serum levels of neopterin and soluble interleukin-2 receptor in intrahepatic cholestasis of pregnancy. Acta Obstetricia et Gynecologica Scandinavica 2004; 83: 1067–70. https://doi.org/10.1111/j.0001-6349.2004.00601.x.

Wasmuth HE, Glantz A, Keppeler H, Simon E, Bartz C, Rath W, Mattsson LA, Marschall HU, Lammert F. Intrahepatic cholestasis of pregnancy: the severe form is associated with common variants of the hepatobiliary phospholipid transporter ABCB4 gene. Gut 2007; 56: 265–70. https://doi.org/10.1136/gut.2006.092742.

Waspe J, Beronius A. Development of an adverse outcome pathway for intrahepatic cholestasis of pregnancy. Current Research in Toxicology 2022; 3: 100065. https://doi.org/10.1016/j.crtox.2022.100065.

Webb G, Elsharkawy A, Hirschfield G. The etiology of intrahepatic cholestasis of pregnancy: towards solving a monkey puzzle. American Journal of Gastroenterology 2014; 109: 85–88. https://doi.org/10.1038/ajg.2013.437.

Webster J, Chappell L, Cheng F, Breeze ACG, Lucas N, Plaat F, Williamson C. Operative delivery rates following induction of labour for obstetric cholestasis. Obstetric Medicine: The Medicine of Pregnancy 2011; 4: 66–9. https://doi.org/10.1258%2Fom.2011.110080.

Wikström Shemer E, Marschall HU. Decreased 1,25-dihydroxy vitamin D levels in women with intrahepatic cholestasis of pregnancy. Acta Obstetricia et Gynecologica Scandinavica 2010; 89: 1420–3. https://doi.org/10.3109/00016349.2010.515665.

Wikström Shemer EA, Stephansson O, Thuresson M, Thorsell M, Ludvigsson JF, Marschall HU. Intrahepatic cholestasis of pregnancy and cancer, immune-mediated and cardiovascular diseases: a population-based cohort study. Journal of Hepatology 2015; 63(2): 456–61. https://doi.org/10.1016/j.jhep.2015.03.010.

Wikström Shemer EA, Thorsell M, Marschall HU, Kaijser M. Risks of emergency cesarean section and fetal asphyxia after induction of labor in intrahepatic cholestasis of pregnancy: a hospital-based retrospective cohort study. Sexual & Reproductive Healthcare 2013; 4: 17–22. https://doi.org/10.1016/j.srhc.2012.11.005.

Wikström Shemer E, Marschall HU, Ludvigsson J, Stephansson O. Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. British Journal of Obstetrics and Gynaecology 2013; 120: 717–23. https://doi.org/10.1111/1471-0528.12174.

Williamson C, Geenes V Intrahepatic cholestasis of pregnancy. Obstetrics & Gynecology 2014; 124: 120–33. https://doi.org/10.1097/AOG.0000000000000346.

Williamson C, Gorelik J, Eaton BM, Lab M, de Swiet M, Korchev Y. The bile acid taurocholate impairs rat cardiomyocyte function: a proposed mechanism for intrauterine fetal death in obstetric cholestasis. Clinical Science (Lond) 2001; 100: 363–9. https://doi.org/10.1042/cs1000363

Williamson C, Hems LM, Goulis DG, Walker I, Chambers J, Donaldson O, de Swiet M, Johnston DG. Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group. British Journal of Obstetrics and Gynaecology 2004; 111: 676–81. https://doi.org/10.1111/j.1471-0528.2004.00167.x.

Williamson C, Miragoli M, Sheikh Abdul Kadir S, Abu-Hayyeh S, Papacleovoulou G, Geenes V, Gorelik J. Bile acid signaling in fetal tissues: implications for intrahepatic cholestasis of pregnancy. Digestive Diseases 2011; 29(1): 58–61. https://doi.org/10.1159/000324130.

Wojcicka J, Sienko J, Smolarczyk R, Romejko E, Grymowicz M, Czajkowski K. Alpha-hydroxybutyrate dehydrogenase activity in intrahepatic cholestasis of pregnancy. International Journal of Gynecology & Obstetrics 2005; 89: 247–50. https://doi.org/10.1016/j.ijgo.2005.02.015.

Wójcicka-Jagodzińska J, Kuczyńska-Sicińska J, Czajkowski K, Smolarczyk R. Carbohydrate metabolism in the course of intrahepatic cholestasis in pregnancy. American Journal of Obstetrics & Gynecology 1989; 161: 959–64. https://doi.org/10.1016/0002-9378(89)90762-X.

Wolf MF, Sgayer I, Yaron L, Shnaider O, Odeh M, Bornstein J, Carmiel M. Intrahepatic cholestasis of pregnancy – prevalence and ethnic distribution in northern Israel. Ginekologia Polska 2022; 93(7): 578–84. https://doi.org/10.5603/gp.a2021.0172.

X

Xu Z, Ke JC, Xing AY. [Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy] (in Chinese). Sichuan Da Xue Xue Bao Yi Xue Ban 2008; 39: 430–3. https://pubmed.ncbi.nlm.nih.gov/18575333/.

Y

Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. Journal of Biological Chemistry 2006; 281: 16625–31. https://doi.org/10.1074/jbc.M602723200.

Yang S, Platt RW, Kramer MS. Variation in child cognitive ability by week of gestation among healthy term births. American Journal of Epidemiology 2010; 171: 399–406. https://doi.org/10.1093/aje/kwp413.

Yang X, Zhang C, Williamson C, Liu Y, Zhou Y, Liu C, Chen L, Zhang Y, Korevaar T, Wu W, Fan J. Association of maternal thyroid function with gestational hypercholanemia. Thyroid 2022; 32(1): 97–104. https://doi.org/10.1089/thy.2021.0242.

Yerushalmi B, Sokol RJ, Narkewicz MR, Smith D, Karrer FM. Use of rifampin for severe pruritus in children with chronic cholestasis. Journal of Pediatric Gastroenterology & Nutrition 1999; 29: 442–7. https://doi.org/10.1097/00005176-199910000-00013.

Ylöstalo P, Kirkinen P, Heikkinen J, Mäentausta O, Järvinen PA. Gall bladder volume and serum bile acids in cholestasis of pregnancy. British Journal of Obstetrics and Gynaecology 1982; 89: 59–61. https://doi.org/10.1111/j.1471-0528.1982.tb04636.x.

Ylötalo P, Kirkinen P, Heikkinen J, Mäentausta O. Gallbladder volume in cholestasis of pregnancy. New England Journal of Medicine 1981; 304: 359. https://doi.org/10.1056/NEJM198102053040615.

Z

Zapata R, Sandoval L, Palma J, Hernández I, Ribalta J, Reyes H, Sedano M, Tohá D, Silva JJ. Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy. A 12-year experience. Liver International 2005; 25: 548–54. https://doi.org/10.1111/j.1478-3231.2004.0996.x.

Zecca E, Costa S, Lauriola V, Vento G, Papacci P, Romagnoli C. Bile acid pneumonia: a "new" form of neonatal respiratory distress syndrome? Pediatrics 2004; 114: 269–72. https://doi.org/10.1542/peds.114.1.269.

Zecca E, De Luca D, Marras M, Caruso A, Bernardini T, Romagnoli C. Intrahepatic cholestasis of pregnancy and neonatal respiratory distress syndrome. Pediatrics 2006; 117: 1669–72. https://doi.org/10.1542/peds.2005-1801.

Zecca E, De Luca D, Baroni S, Vento G, Tiberi E, Romagnoli C. Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fluid study. Pediatrics 2008; 121: e146–e149. https://doi.org/10.1542/peds.2007-1220.

Zhang J, Liu H, Tang L, Lin H, Yao Y, Tong Y, Jin M, Wang K. Pharmacokinetics and food impact assessment of ademetionine enteric-coated tablet as an endogenous substance drug in healthy Chinese volunteers. Journal of Clinical Pharmacy and Therapeutics 2022; 47(6): 738–44. https://doi.org/10.1111/jcpt.13601.

Zhang Y, Li F, Wang Y, Pitre A, Fang Z, Frank MW, Calabrese C, Krausz KW, Neale G, Frase S, Vogel P, Rock CO, Gonzalez FJ, Schuetza JD. Maternal bile acid transporter deficiency promotes neonatal demise. Nature Communications 2015; 6: 8186. https://doi.org/10.1038/ncomms9186.

Zhang QW, Huang M, Gong YH, Li T, Liu XH. [Perinatal outcomes of using ursodeoxycholic acid to treat monochorionic and dichorionic twin pregnancy complicated by intrahepatic cholestasis of pregnancy]. Sichuan Da Xue Xue Bao Yi Xue Ban 2022; 53(1): 137–41. https://doi.org/10.12182/20220160506.

Zhao C, Wang X, Cong Y, Deng Y, Xu Y, Chen A, Yin Y. Effects of bile acids and the bile acid receptor FXR agonist on the respiratory rhythm in the in vitro brainstem medulla slice of neonatal Sprague–Dawley rats. PLOS ONE 2014; 9: e112212. https://doi.org/10.1371/journal.pone.0112212.

Zhou F, Gao B, Wang X, Li J. [Meta-analysis of ursodeoxycholic acid and S-adenosylmethionine for improving the outcomes of intrahepatic cholestasis of pregnancy] (in Chinese). Zhonghua Gan Zang Bing Za Zhi 2014; 22: 299–304. https://doi.org/10.3760/cma.j.issn.1007-3418.2014.04.013.

Zimber A, Zusman I. Effects of secondary bile acids on the intrauterine development in rats. Teratology 1990; 42: 215–24. https://doi.org/10.1002/tera.1420420305.

Zöllner J, Finer S, Linton KJ, Genes and Health Research Team, van Heel DA, Williamson W, Dixon PH. Rare variant contribution to cholestatic liver disease in a South Asian population in the United Kingdom. Scientific Reports 2023; 13(8120). https://doi.org/10.1038/s41598-023-33391-w.

Zu Y, Guo S, Li G, Gao Q, Wang X, Zhang C, Liu D. Serum microRNAs as non-invasive diagnostic biomarkers for intrahepatic cholestasis of pregnancy. American Journal of Translational Research 2022; 14(9): 6763–73. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9556493/.